Extended Data Fig. 6: Fat- and sucrose-responsive dHPC neurons are not required for working memory or sufficient to influence memory in the wrong context.
A Schematic of nutrient-related Barnes maze test. B Number of errors in locating the sucrose location on first and second trial in dHPCSugar mice without viral-mediated ablation (N = 7/group, Paired Student’s t test). C Number of errors in locating the sucrose location on first and second trial in dHPCSugar mice with viral-mediated ablation (N = 6/group, Paired Student’s t test). D Number of errors in locating the fat location on first and second trial in dHPCSugar mice without viral-mediated ablation (N = 7/group, Paired Student’s t test). E Number of errors in locating the fat location on first and second trial in dHPCSugar mice with viral-mediated ablation (N = 6/group, Paired Student’s t test). F Number of errors in locating the sucrose location on first and second trial in dHPCFat mice without viral-mediated ablation (N = 9/group, Paired Student’s t test). G Number of errors in locating the sucrose location on first and second trial in dHPCFat mice with viral-mediated ablation (N = 7/group, Paired Student’s t test). H Number of errors in locating the fat location on first and second trial in dHPCFat mice without viral-mediated ablation (N = 9/group, Paired Student’s t test). I Number of errors in locating the fat location on first and second trial in dHPCFat mice with viral-mediated ablation (N = 7/group, Paired Student’s t test). J Control experiment for Fig. 4g. Discrimination of fat quadrant in response to saline and CNO in dHPCSugar mice expressing viral-mediated hM3Dq or control (N = 5-8/group, Paired Student’s t test). K Control experiment for Fig. 4h. Discrimination of sucrose quadrant in response to saline and CNO in dHPCFat mice expressing viral-mediated hM3Dq or control (N = 6-7/group, Paired Student’s t test). Data are presented as mean ± s.e.m. *P < 0.05, **P < 0.01, ns, not significant. Elements of this figure were created in BioRender. Lab, D. (2024) BioRender.com/c40u835.
