Extended Data Fig. 7: Fat- and sucrose-responsive dHPC neurons are not required for learning.
A Number of sucrose infusions received during conditioning tests from Fig. 5b, c and f (N = 6-8, Two-way ANOVA with Holm-Sidak post hoc analysis). B. Number of fat infusions received during conditioning tests from Fig. 5b, c and f (N = 5-7, Two-way ANOVA with Holm-Sidak post hoc analysis). C Preference for fat paired flavor after restricting conditioning infusions in control mice to match the number of ablation of fat-responsive dHPC neurons (N = 9/group, Paired Student’s t test). D Sucrose lick number for active and inactive sippers during conditioning session for dHPCSugar mice with control or caspase virus (N = 7, Two-way ANOVA with Holm-Sidak post hoc analysis). E Fat lick number for active and inactive sippers during conditioning session for dHPCFat mice with control or caspase virus (N = 9-10, Two-way ANOVA with Holm-Sidak post hoc analysis). F Breakpoint for sucrose reward in dHPCFat mice with control or caspase virus (N = 6, Two-way ANOVA with Holm-Sidak post hoc analysis). G Sucrose lick number for active and inactive sippers during conditioning session for dHPCFat mice with control or caspase virus (N = 6, Two-way ANOVA with Holm-Sidak post hoc analysis). H Sucrose lick number for active and inactive sippers during conditioning session for dHPCSucrose mice with control or hM3Dq virus (N = 6-11, Two-way ANOVA with Holm-Sidak post hoc analysis). I Fat lick number for active and inactive sippers during conditioning session for dHPCFat mice with control or hM3Dq virus (N = 10-12, Two-way ANOVA with Holm-Sidak post hoc analysis). Data are presented as mean ± s.e.m. *P < 0.05, ns, not significant.
