Extended Data Fig. 9: Deletion of dHPCSugar neurons decreases meal number in the dark phase and prevents weight gain over 4 weeks. | Nature Metabolism

Extended Data Fig. 9: Deletion of dHPCSugar neurons decreases meal number in the dark phase and prevents weight gain over 4 weeks.

From: Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation

Extended Data Fig. 9: Deletion of dHPCSugar neurons decreases meal number in the dark phase and prevents weight gain over 4 weeks.

A Dark phase meal pattern analysis of 45% HFHS diet in dHPCSugar mice with viral-mediated ablation (N = 11-12/group, unpaired t-test). B Light phase meal pattern analysis of 45% HFHS diet in dHPCSugar mice with viral-mediated ablation (N = 11-12/group, unpaired t-test). C Comparing percent weight gain at 2 and 4 weeks between dHPCSugar mice with viral-mediated ablation (N = 9/group, two-way ANOVA with Holm-Sidak post hoc analysis). D Comparing percent fat mass accumulation at 2 and 4 weeks between dHPCSugar mice with viral-mediated ablation (N = 9/group, two-way ANOVA with Holm-Sidak post hoc analysis). E Cumulative hourly food intake in control mice in response to saline and CNO (N = 5, Two-way RM ANOVA with Holm-Sidak post-hoc analysis).

Source data

Back to article page