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UPRmt controls the mesenchymal-to-epithelial transition

Nature Metabolism volume 7, pages 871–872 (2025)Cite this article

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The mitochondrial unfolded protein response (UPRmt) is a transcriptional program that is activated in cells experiencing mitochondrial stress and that helps to return to proteostasis and improve stress resistance. Ying et al. reveal that the UPRmt controls the mesenchymal-to-epithelial transition during the acquisition of pluripotency.

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Fig. 1: JUN links the UPRmt to the MET during reprogramming.

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Authors and Affiliations

  1. Program in Metabolic Biology, Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA, USA

    Marine Barthez & Danica Chen

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  1. Marine Barthez
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  2. Danica Chen
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Correspondence to Danica Chen.

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The authors declare no competing interests.

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Barthez, M., Chen, D. UPRmt controls the mesenchymal-to-epithelial transition. Nat Metab 7, 871–872 (2025). https://doi.org/10.1038/s42255-025-01260-7

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