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Gut hormones

A gut hormone governing protein appetite and longevity

A study in Nature Metabolism reports a protein-responsive gut hormone that regulates appetite, sleep and organismal lifespan. This finding sheds light on the evolutionarily conserved endocrine system that controls dietary protein intake.

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Fig. 1: Endocrine regulation of protein appetite, sleep and longevity by gut hormones.

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Correspondence to Fumiaki Obata.

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Sakuma, C., Obata, F. A gut hormone governing protein appetite and longevity. Nat Metab 7, 1109–1110 (2025). https://doi.org/10.1038/s42255-025-01278-x

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