Fig. 4: Global germline loss of either Gipr or Glp-1r blocks GIPR antagonism-mediated effects on body weight and food intake. | Nature Metabolism

Fig. 4: Global germline loss of either Gipr or Glp-1r blocks GIPR antagonism-mediated effects on body weight and food intake.

From: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

Fig. 4: Global germline loss of either Gipr or Glp-1r blocks GIPR antagonism-mediated effects on body weight and food intake.The alternative text for this image may have been generated using AI.

a–c, Body weight in grams (a) and percent (b) and food intake (c) of HFD-fed 14–16-week-old male C57BL6/J WT mice treated s.c. with a single dose (30 mg kg−1) of either a control mAb (vehicle; n = 5) or an anti-GIPR antagonist (ant.) antibody (n = 6). d–f, Body weight in grams (d) and percent (e) and food intake (f) of HFD-fed 14–16-week-old male C57BL6/J global Gipr KO mice treated s.c. with a single dose (30 mg kg−1) of either a control mAb (vehicle) or an anti-GIPR antagonist antibody (n = 6 each group). g–i, Body weight in grams (g) and percent (h) and food intake (i) of HFD-fed 14–16-week-old male C57BL6/J global Glp-1r KO mice treated s.c. with a single dose (30 mg kg−1) of either a control mAb (vehicle) or an anti-GIPR antibody (n = 6 each group). Data represent mean ± s.e.m. *P < 0.05, **P < 0.01 and ***P < 0.001. Data in a–i were analysed by a two-way ANOVA with Bonferroni’s post hoc test for comparison of individual timepoints.

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