Extended Data Fig. 4: Characterization of CNS GIPR Knockout mice. | Nature Metabolism

Extended Data Fig. 4: Characterization of CNS GIPR Knockout mice.

From: GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice

Extended Data Fig. 4: Characterization of CNS GIPR Knockout mice.

Plasma biomarker levels were assessed in two separate cohorts of mice. Plasma (a) total cholesterol, (b) triglycerides, (c) high density lipoprotein (HDL) cholesterol, and (d) low density lipoprotein (LDL) cholesterol were measured in Giprfl/fl (n=8) and GiprSyn−/− mice (n=8). In a separate cohort (given sample constraints), plasma levels of (e) leptin, (f) adiponectin, (g) resistin, (h) Interleukin-6 (IL-6), (i) tumor necrosis factor alpha (TNF), and (j) monocyte chemoattractant protein-1 (MCP-1) were measured in Giprfl/fl (n=8) and GiprSyn−/− (n=14) mice. (A-J) Two-tailed unpaired t test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 vs. Giprfl/fl control.

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