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GLP-1-mediated synaptic plasticity in feeding regulation is modulated by energy state

Nature Metabolism volume 7, pages 1318–1319 (2025)Cite this article

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Glucagon-like peptide 1 (GLP-1) receptor-expressing neurons in the paraventricular nucleus of the hypothalamus send descending excitatory projections to the dorsal vagal complex of the brainstem. GLP-1 signalling regulates synaptic transmission in this circuit in an energy state-dependent manner to control feeding and energy homeostasis.

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Fig. 1: Energy state-dependent GLP-1 regulation of a descending PVNGLP-1R–DVC circuit and feeding behaviour.

References

  1. Drucker, D. J. GLP-1 physiology informs the pharmacotherapy of obesity. Mol. Metab. 57, 101351 (2022). A review article that provides an excellent overview of GLP-1 and GLP-1 analogues.

    Article  CAS  PubMed  Google Scholar 

  2. Brierley, D. I. et al. Central and peripheral GLP-1 systems independently suppress eating. Nat. Metab. 3, 258 (2021). A paper that reports that central and peripheral GLP-1 action independently controls feeding behaviour.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kirchgessner, A. L. & Sclafani, A. PVN-hindbrain pathway involved in the hypothalamic hyperphagia-obesity syndrome. Physiol. Behav. 42, 517 (1988). A paper that reports that lesion of a PVN descending pathway induces obesity.

    Article  CAS  PubMed  Google Scholar 

  4. Williams, E. K. et al. Sensory neurons that detect stretch and nutrients in the digestive system. Cell 166, 209 (2016). A paper that reports that vagal GLP-1R neurons are involved in gut-to-brain communication.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. van den Pol, A. N. Neuropeptide transmission in brain circuits. Neuron 76, 98–115 (2012). A review article that provides an overview of neuropeptidergic regulation and function in the brain.

    Article  PubMed  PubMed Central  Google Scholar 

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This is a summary of: Wang, L. et al. State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis. Nat. Metab. https://doi.org/10.1038/s42255-025-01305-x (2025).

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GLP-1-mediated synaptic plasticity in feeding regulation is modulated by energy state. Nat Metab 7, 1318–1319 (2025). https://doi.org/10.1038/s42255-025-01304-y

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