Extended Data Fig. 1: Study flowchart.

(a) Study key dates and (b) CONSORT flow diagram illustrating the study procedures, data collection and analysis. Missing data was described in Supplementary Table 3. HRA, Health Research Authority.

(a) Study key dates and (b) CONSORT flow diagram illustrating the study procedures, data collection and analysis. Missing data was described in Supplementary Table 3. HRA, Health Research Authority.