Extended Data Fig. 3: Distinct correlation patterns between oral-typical bacteria and MASLD-associated metabolites in non-lean vs. lean MASLD.
a. The correlations between oral-typical bacteria and metabolites vary between non-lean and lean MASLD cases. The analysis includes all oral-typical bacteria and MASLD-associated metabolites. Dot size represents the magnitude of the absolute difference in correlations between non-lean and lean MASLD cases (that is, |⍴(bacteria and metabolites) for non-lean - ⍴(bacteria and metabolites) for lean|). Dot colour reflects the directionality of the correlations in each group: for example, green dots signify correlations that are negative for non-lean and positive for lean MASLD, whereas blue dots indicate correlations that are positive for non-lean and negative for lean MASLD, respectively. This visualization highlights the nuanced interplay between oral-typical microbes and metabolites across MASLD phenotypes. b. Selected microbe-metabolite pairs show different interaction patterns between non-lean vs. lean MASLD (Supplementary Table 9). Spearman correlation test was used to fit the line with the corresponding two-sided p-value shown. Bacteria are arcsine square root transformed and metabolites are log2 transformed.
