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Immunometabolism

Macrophages say NO to nucleotide synthesis and salvage instead

Nature Metabolism volume 7, pages 1505–1506 (2025)Cite this article

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Metabolic reprogramming is a well-established hallmark of macrophage activation, coordinating bioenergetic and biosynthetic pathways to support immune effector functions. A new study now reveals a previously unappreciated, system-wide remodelling of nucleotide metabolism driven by nitric oxide (NO), with important implications for inflammatory macrophage function and host–pathogen interactions.

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Fig. 1: NO-driven nucleotide metabolism remodelling in macrophages.

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  1. MRC Mitochondrial Biology Unit, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK

    Eloïse Marques & Dylan G. Ryan

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  1. Eloïse Marques
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  2. Dylan G. Ryan
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Correspondence to Dylan G. Ryan.

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The authors declare no competing interests.

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Marques, E., Ryan, D.G. Macrophages say NO to nucleotide synthesis and salvage instead. Nat Metab 7, 1505–1506 (2025). https://doi.org/10.1038/s42255-025-01322-w

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