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Metabolism

Much ado about NAA-thing

Nature Metabolism volume 7, pages 1498–1500 (2025)Cite this article

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A recent study in Nature Metabolism by Felix et al. reveals that the breakdown of N-acetylaspartate (NAA) by the enzyme aspartoacylase (encoded by Aspa) in adipocytes has a crucial role in regulating circulating NAA levels, maintaining systemic glucose homeostasis and controlling postprandial body temperature.

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Fig. 1: The breakdown of NAA in adipocytes controls postprandial body temperature in mice.

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Authors and Affiliations

  1. Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA

    Jan-Bernd Funcke & Philipp E. Scherer

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  1. Jan-Bernd Funcke
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  2. Philipp E. Scherer
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Correspondence to Philipp E. Scherer.

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Funcke, JB., Scherer, P.E. Much ado about NAA-thing. Nat Metab 7, 1498–1500 (2025). https://doi.org/10.1038/s42255-025-01327-5

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