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Adipose tissue

Infant ketones set the thermogenic tone

Nature Metabolism volume 7, pages 1963–1964 (2025)Cite this article

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Infant ketones during breastfeeding reprogram adipose progenitors via epigenetic modifications, driving beige fat development. This confers lifelong obesity resistance and prevents metabolic disease.

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Fig. 1: Context-dependent functions of βHB signalling.

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Authors and Affiliations

  1. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu, China

    Jing Wang & Da Jia

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  1. Jing Wang
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  2. Da Jia
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Correspondence to Da Jia.

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The authors declare no competing interests.

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Wang, J., Jia, D. Infant ketones set the thermogenic tone. Nat Metab 7, 1963–1964 (2025). https://doi.org/10.1038/s42255-025-01357-z

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