Extended Data Fig. 4: Low dose 13 C itaconate treatment reveals itaconate dynamics in vivo.
From: In vivo itaconate tracing reveals degradation pathway and turnover kinetics
a, Plasma itaconate. b, Isotopologue distribution from [U-13C5]itaconate on plasma itaconate. c, Plasma metabolite levels. d, Itaconate levels in liver. Isotopologue distribution from [U-13C5]itaconate on liver e, itaconate f, citrate, and g, α-ketoglutarate. h, itaconate levels in the urine. Mice were injected with low - dose 40 mg kg−1 body weight [U-13C5]itaconate. Data are presented as means ± s.e.m. from n = 3 mice. Multiple paired t-test (a, c) with P > 0.05.
