Extended Data Fig. 5: The fate of 13 C itaconate in kidney tissue.
From: In vivo itaconate tracing reveals degradation pathway and turnover kinetics
a-k Isotopologue distribution from [U-13C5]itaconate on a, itaconate, b, pyruvate, c, lactate, d, alanine, e, citrate, f, α-ketoglutarate, g, glutamate, h, succinate, i, fumarate, j, malate, and k, aspartate in kidney tissue. Schematic of [U-13C5]itaconate use for TCA cycle metabolism with open circles depicting 12C and closed circles 13C. Mice were injected with 400 mg kg−1 body weight [U-13C5]itaconate. Data are presented as means ± s.e.m. with tissue samples at 0 min (n = 4), 15 min (n = 5), and 45 min (n = 4). P values were calculated by multiple unpaired t-test with *P < 0.05, **P < 0.01, ***P < 0.001. Exact P-values are indicated in each figure panel.
