Extended Data Fig. 4: Extended lipidomic analysis of human isogenic APOE3/3 and APOE4/4 iAstrocytes.
From: The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
a-c) Volcano plots of lipid species changed in ApoE4 vs ApoE3 iAstrocytes in the independent replicate experiments in Kolf2.1J set #1 (a), BIONi037 (b) or Kolf2.1J set #2 (c). d) Bar graphs of lipid class levels in ApoE3 and ApoE4 iAstrocytes from all datasets presented in Fig. 3f. N=9, three independent experiments from three isogenic sets, Mean + sd. e-f) Fold change of cholesterol ester (e) or phospholipid (f) species with indicated number of double bonds in ApoE4 vs ApoE3 iAstrocytes. Mean. In all panels open circles indicate mean per experiment, while solid dots represent all independent wells.
