Extended Data Fig. 5: T2D Hard Cluster Polygenic Score Differences in Unsolved MODY Cases Compared to Controls.
From: Common genetic variants modify disease risk and clinical presentation in monogenic diabetes
Mean polygenic score differences for T2D hard cluster partitioned scores in Unsolved MODY cases (pink, N = 300) compared to non-diabetic controls (dashed black line, N = 7,645). Scores are standardized with controls set to a mean of 0 and a standard deviation of 1. Error bars represent 95% confidence intervals, and dots indicate the mean estimates. Asterisks denote statistically significant differences from controls (P < 0.006), based on the Bonferroni significance threshold, as determined by linear regression models adjusted for the first ten within-cohort principal components.
