Fig. 4: SNP-based heritability estimates for MODY.
From: Common genetic variants modify disease risk and clinical presentation in monogenic diabetes
SNP-based h² estimates were calculated in unrelated individuals using GCTA GREML-LDMS, stratified into four LD bins of equal size to construct the genetic relationship matrix, with sex, age and the first ten principal components within the cohort as covariates. Bars represent heritability point estimates and error bars represent the 95% confidence intervals. Estimates for HNF-MODY carriers (n = 864) and T2D cases (n = 4,461) were compared with non-diabetic controls (n = 6,935). h² is shown on the liability scale for T2D (prevalence, 0.1) and MODY (prevalence, 0.0005). MODY and T2D cases were compared, adjusting for T2D polygenic score.
