Extended Data Fig. 7: SLC25A51 overexpression influences the plasma metabolome during liver regeneration.
From: Hepatocyte mitochondrial NAD+ content is limiting for liver regeneration
Metabolomic profile of plasma acquired from SLC25A51 overexpressing (OE) and eGFP control mice pre and 48 h post hepatectomy. a-b, Depleted and enriched metabolites during regeneration in eGFP (a) and A51 overexpressing (b) mice. Significant metabolites were determined by p < 0.05 from an unpaired two-tailed Student’s t-test. c, Correlation plots of log2 fold change were plotted from plasma by selecting all significant metabolites within the eGFP comparison alone, OE comparison alone or a shared (common) subset. d-e, Joint pathway analysis of significant metabolites and proteins (p < 0.05 from Student’s t-test) from liver tissue of eGFP controls (d) and SLC25A51 overexpressing (e) livers using MetaboAnalyst 6.045, (n = 5 mice for eGFP control and n = 6-8 for A51 OE).
