Extended Data Fig. 2: Pathway analysis for hepatic significant genes. | Nature Metabolism

Extended Data Fig. 2: Pathway analysis for hepatic significant genes.

From: Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

Extended Data Fig. 2

(a) Gene ontology analysis for down- and up-regulated HFD-responsive genes. (b) Signaling pathway impact analysis (SPIA) for HFD-responsive genes was conducted as described80. Pathways respectively on the right-hand side of the red and blue curves are significant after Bonferroni correction of the global p-values (pG) obtained by combining the pPERT and pNDE using the normal inversion method, and significant after a FDR correction of pG using the Benjamini – Yekutieli method. Significant KEGG pathways: 04141, Protein processing in the endoplasmic reticulum; 04710, Circadian rhythm; 04152, AMPK signaling pathway. Source data are provided.

Source data

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