In this issue of Nature Metabolism, Neri et al. show that two distinct stellate ganglion subcircuits innervating interscapular brown adipose tissue (iBAT) separately control thermogenesis and glucose tolerance, providing a mechanistic explanation for temperature-independent benefits of iBAT on glycaemia.
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References
Olsen, J. M. et al. Mol. Metab. 6, 611–619 (2017).
Weir, G. et al. Cell Metab. 27, 1348–1355 (2018).
Blondin, D. P. et al. Diabetes 64, 2388–2397 (2015).
Gibbins, I. L. J. Auton. Nerv. Syst. 34, 171–183 (1991).
Zhu, Y. et al. Nature 634, 243–250 (2024).
Neri, D. et al. Nat. Metab. https://doi.org/10.1038/s42255-025-01429-0 (2026).
Wang, T. et al. Nature 637, 895–902 (2025).
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We acknowledge support from the US National Institutes of Health, Howard Hughes Medical Institute and Chan-Zuckerberg Initiative.
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Huang, X., Ye, L. Heterogeneous sympathetic control of brown adipose tissue. Nat Metab (2026). https://doi.org/10.1038/s42255-025-01435-2
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DOI: https://doi.org/10.1038/s42255-025-01435-2
