Fig. 3: Distribution of differences between EUR and non-EUR in the minor allele frequency of IVs for genes and proteins only tested in non-EUR. | Nature Metabolism

Fig. 3: Distribution of differences between EUR and non-EUR in the minor allele frequency of IVs for genes and proteins only tested in non-EUR.

From: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues

Fig. 3: Distribution of differences between EUR and non-EUR in the minor allele frequency of IVs for genes and proteins only tested in non-EUR.The alternative text for this image may have been generated using AI.

The differences were computed as \({\mathrm{MAF}}_{\mathrm{non}-\mathrm{EUR}}-{\mathrm{MAF}}_{\mathrm{EUR}}\). Minor allele frequencies (MAFs) were obtained from the Genome Aggregation Database (gnomAD)78. gnomADg_NFE_MAF refers to the MAF observed in gnomAD genomes in the non-Finnish European (NFE) population. Positive differences—that is, IVs for which the MAF is lower in NFE than in the corresponding non-EUR ancestry group—are represented in red, and negative differences in grey. Boxplots represent the median (centre line) and the 25th and 75th percentiles (box bounds), with whiskers extending to 1.5× the interquartile range (IQR) from the box. Number of IVs included genes only tested in AFR (n = 1,539 IVs) and AMR (n = 7,262 IVs), and proteins only tested in AFR (n = 462 IVs) and EAS (n = 231 IVs).

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