Fig. 5: Overview of the results from the eQTL EUR MR analyses in T2D-relevant tissues. | Nature Metabolism

Fig. 5: Overview of the results from the eQTL EUR MR analyses in T2D-relevant tissues.

From: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues

Fig. 5: Overview of the results from the eQTL EUR MR analyses in T2D-relevant tissues.The alternative text for this image may have been generated using AI.

a, Number of genes tested in MR analyses from T2D-relevant tissues with significant causal effects on T2D risk, percentage of causal effects also detected in blood eQTL MR and percentage of causal effects detected in a tissue where the gene is also expressed. b, Pairwise overlap of significant causal effects across T2D-relevant tissues and blood eQTL MR. For easier reading, only pairwise overlap between different tissues is represented. c, Distribution of I2 values representing the heterogeneity of causal estimates for genes tested in at least two tissues (including blood).

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