Table 1 Molecular traits (genes and proteins) with evidence of causal effects on T2D risk from eQTL and pQTL MR

From: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues

 

eQTL

Blood

Subcutaneous adipose

Visceral adipose

Brain hypothalamus

Liver

Skeletal muscle

Pancreas

Pancreatic islets

 

No. of significant causal effects

335

243

186

90

70

217

139

131

pQTL

EUR (n = 39)

HIBCH*

CPXM1* HIBCH* HYAL1

HIBCH*

-

GSTA1*

CPXM1* HIBCH*

GSTA1*

PTGFRN HIBCH*

AFR (n = 0)

-

-

-

-

-

-

-

-

EAS (n = 8)

-

-

-

-

-

BOC FAM20B

-

-

Meta-analysis (n = 5)

-

-

-

-

-

-

-

-

  1. *Replicated in at least one independent ancestry-matched cohort; that is, with q < 0.05 in the replication cohort and concordant direction of effect with the discovery cohort
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