Metabolism regulates cell fates through the epigenome. Wang, Shi et al. demonstrate that the cell fates of pluripotency, differentiation and ageing emerge from how a nuclear protein channels metabolic fluxes into distinct epigenetic marks by regulating expression of metabolic genes.
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Huang, D., Dai, Z. Methylation, acetylation and cell fate. Nat Metab (2026). https://doi.org/10.1038/s42255-025-01449-w
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DOI: https://doi.org/10.1038/s42255-025-01449-w
