By determining the organellar topology and proteome of fat-oxidizing and fat-synthesizing hepatocytes, Kang et al. show that perilipin 5-mediated mitochondria–lipid droplet contacts facilitate the expansion of lipid droplets in both populations and are impaired in early metabolic dysfunction-associated steatotic liver disease (MASLD).
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M.L. is a co‐founder of Enspire Bio LLC, was a consultant for Capacity Bio and has received sponsored research agreements from Bantam Pharmaceutical, Janssen and Amgen, and a technical support contract with Senergy Bio. J.S. declares no competing interests.
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Segalés, J., Liesa, M. The expanding role of mitochondria–lipid droplet contacts in liver and their disruption by MASLD. Nat Metab 8, 527–528 (2026). https://doi.org/10.1038/s42255-026-01483-2
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DOI: https://doi.org/10.1038/s42255-026-01483-2
