KRAS mutations in colorectal cancers shape an immunosuppressive tumour microenvironment. In this issue of Nature Metabolism, Yang et al. report that TRIP6 phosphorylation-induced glycolysis in KRAS-mutant colorectal cancer impedes CD8+ T cell function by the intriguing extracellular lactylation of CD44.
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Xu, N., Tong, X. TRIPping anti-tumour immunity through lactylation. Nat Metab (2026). https://doi.org/10.1038/s42255-026-01486-z
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DOI: https://doi.org/10.1038/s42255-026-01486-z
