Extended Data Fig. 1: Metformin acutely improves glucose tolerance in non-diabetic humans.
From: Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control
(a) Schematic illustrating sample collection and metformin dosing in the Rotroff et al. cohort (same as Fig. 1a); related to panels (b) and (c). Created in BioRender. Chandel, N. (2026) https://BioRender.com/wg2lxg7. (b) Glucose tolerance test in the Rotroff et al. cohort of non-diabetic subjects before and after metformin treatment. (c) Area under the curve of (b); n = 33. OGTT = oral glucose tolerance test. For (b), data are presented as mean ± SEM. Statistical significance for (c) was determined by two-sided paired t test. ****P < 0.0001.
