Extended Data Fig. 8: Glucosamine treatment and PGM3 knockdown do not induce astrocytosis or Aβ deposition in WT mice.
From: Hyperglycosylation is a metabolic driver of Alzheimer’s disease
a, Immunofluorescence images of GFAP and Aβ in brains from WT mice treated with water or glucosamine, showing similar astrocyte staining and absence of Aβ signal between groups. b, GFAP and Aβ staining in WT mice injected with shScr or shPGM3 lentivirus, demonstrating comparable astrocyte morphology and no detectable Aβ accumulation in either condition. Experiments are repeated three times with the same results.
