Extended Data Fig. 3: PS19 mice display widespread increases in brain N-glycans across regions.
From: Hyperglycosylation is a metabolic driver of Alzheimer’s disease
a, MALDI imaging of representative complex N-glycans in WT and PS19 brains with corresponding violin plots of relative abundance (normalized to TIC) showing significantly higher levels in PS19 mice (P<0.0001, two-tailed t-test). b, Comparative heatmaps of metabolite, lipid, and glycan abundances in distinct brain regions (cortex, hippocampus, cerebellum, thalamus, and hindbrain) from WT and PS19 mice. WT levels are set to 1 while Log2 fold changes indicate significant alterations across regions, with pronounced increases in glycan abundance specifically observed in PS19 brains (n = 3 for each genotype).
