Fig. 4: MHC-II binding specificities for allomorphs without known ligands predicted by ImmuScope.
From: Self-iterative multiple-instance learning enables the prediction of CD4+ T cell immunogenic epitopes
a, Workflow of MHC-II binding specificity evaluation. b, Comparison of ImmuScope with other algorithms in predicting MHC-II binding specificity. Bar plots of KLD distance against the PSFMs from the MHC-II immunopeptidomics data (top); peptide-binding motifs obtained by different methods (bottom). Motif of HLA-DQA1*01:02/DQB1*05:02 is derived from peptide ligands in the MHC Motif Atlas Database (http://mhcmotifatlas.org/). Other MHC-II peptide ligands were derived from the corresponding positive samples in the SA data. Panel a created with BioRender.com.
