Extended Data Fig. 7: PARP inhibition modulates the metabolic phenotype of differentiating macrophages.
CD14+ cells from healthy human donors were isolated and differentiated to mature myeloid cells with IL-4 plus GM-CSF in presence or absence of Olaparib for 5 days (n = 5 donors). Proteomics was performed and the 100 most significantly upregulated proteins (FDR < 0.05) and the 100 most highly upregulated proteins were used to identify GO terms associated with Olaparib treatment (a) and proteins that are associated with the GO-terms shown in (b) are highlighted in the same color.
