Extended Data Fig. 7: Gremlin1 overexpression or treatment of Gremlin1 antibody does not affect CML or AML cell homing to the BM or spleen. | Nature Cancer

Extended Data Fig. 7: Gremlin1 overexpression or treatment of Gremlin1 antibody does not affect CML or AML cell homing to the BM or spleen.

From: A Gremlin 1-expressing splenic niche cell population restrains chronic myeloid leukemia by antagonizing the BMP pathway

Extended Data Fig. 7: Gremlin1 overexpression or treatment of Gremlin1 antibody does not affect CML or AML cell homing to the BM or spleen.

a-b. FACS profiles of homing of SCLtTA/BCR-ABL mouse CML cells to the BM (a) or spleen (b) of Ctrl and MGOE groups (n = 6 mice per group). c-f. FACS profiles of homing of TF1-BA CML cells (c-d) or mv-4-11 AML cells (e-f) to the BM or spleen of recipient mice treated with control IgG or Gremlin1 antibody (n = 5 mice per group). Two-sided unpaired Student’s t-test was used for the statistical analysis. Error bars represent mean ± s.e.m.

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