Comprehensive understanding of the molecular mechanisms that underlie ferroptosis is essential for the development of new anti-tumor therapies. Palmitoylation of GPX4 is now shown to increase its stability and change its cellular localization and thus promote resistance to ferroptosis in cancer.
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Demuynck, R., Saviuk, M. & Krysko, D.V. Palmitoylation regulates ferroptosis and anti-tumor immunity. Nat Cancer 6, 746–748 (2025). https://doi.org/10.1038/s43018-025-00972-9
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DOI: https://doi.org/10.1038/s43018-025-00972-9
