Extended Data Fig. 6: Selected gene regulators and their survival associations in myeloid populations.
Kaplan-Meier curves (top) and feature plots displaying the per-cell AUC scores (bottom) in selected myeloid populations for STAT1 (a), BRCA1 (b), E2F1 (c), E2F8 (d), IRF1 (e), IRF2 (f), IRF7 (g), IRF9 (h), and KLF9 (i) regulons. Gene regulator analysis and regulon identification were performed using pySCENIC on selected myeloid clusters. Kaplan-Meier curves are based on the average AUC value across the selected myeloid populations. The cut-point approach was implemented to stratify patients into either high or low regulon expression groups. Two-sided p-values indicate the significance of a CoxPH model fitted to the regulon AUC score.
