Extended Data Fig. 7: UMAP and dot plot comparisons of validation and discovery cohorts across cell compartments.
UMAP projections and stacked bar charts comparing cellular composition between discovery and validation cohorts across major immune cell compartments. Each panel (a-d) corresponds to a distinct cellular compartment including (a) all cells, (b) NK/T cells, (c) myeloid cells and (d) B cells, erythroblasts and progenitor cells, further subdivided into 5 subpanels (x.1-x.5). Subpanels (x.1-x.2) display UMAPS of both discovery and validation cells colored by cell type (x.1) or sample (x.2). Subpanels (x.3-x.4) show the same UMAPS separated by discovery (x.3) and validation (x.4) cohorts, colored by cell type. Subpanels (x.5) contain stacked bar charts representing the distribution of cells within each cluster across individual samples and separated by cohort. Samples from the discovery cohort are colored different shades of blue, while samples from the validation cohort are colored different shades of red. (e-i) Validation cohort dot plot showing the previously described cluster markers for (e) CD8+ cells, (f) CD4+ cells, (g) natural killer cells, (h) myeloid cells, and (i) B cells, erythroblasts, and progenitor cells.
