Extended Data Fig. 4: Analysis of rituximab levels and number of doses, including correlations with response.
Correlation between rituximab levels in blood and number of rituximab doses (A). Number of rituximab doses taken by patients by best response (B) and ongoing response (C). Peak rituximab levels in blood by (D) best response and (E) ongoing response. Peak rituximab levels were defined as the maximum rituximab level measured after axi-cel infusion. Responses were assessed in the mITT population (N = 26) and by the investigator per Lugano Classification. One patient with ongoing response was lost to follow-up at the time of data cutoff and was excluded (from panels C and E). For panels (D) and (E), box plots show Q1, median, and Q3, and the lower and upper whiskers show the minimum and maximum values excluding outliers, respectively. Axi-cel, axicabtagene ciloleucel; AUC, area under the curve; CR, complete response; mITT, modified intention-to-treat; PD, progressive disease; PR, partial response; Q1, first quartile; Q3, third quartile; SD, stable disease.
