Extended Data Fig. 10: Comparison with previously identified predictive features.
a Overlap in pre-treatment predictive features originally identified in Wang et al. b Overlap in pre-treatment predictive features after running SpaceCat on the data from Wang et al. c Proportion of Ki67+ Cancer cells stratified by response across timepoints in Wang et al., baseline (N = 109, 55 pCR / 54 RD), on treatment (N = 67, 28 pCR / 39 RD) d Proportion of Ki67 + CD8 T cells stratified by response across timepoints in Wang et al., baseline (N = 113, 56 pCR / 57 RD), on treatment (N = 97, 48 pCR / 49 RD) e Density of Cancer cells stratified by response across timepoints in Wang et al., baseline (N = 108, 54 pCR / 54 RD), on treatment (N = 93, 47 pCR / 46 RD) f Comparison of SpaceCat features, original features, and combined features to predict outcome in Wang et al. data g Comparison of SpaceCat features, Wang et al. features, and combined features to predict outcome in TONIC data h Overlap in on-treatment predictive features originally identified in Wang et al. (4.2) i Overlap in on-treatment predictive features after running SpaceCat on the data from Wang et al. j Distribution of top features across timepoints when using only features defined in Wang et al. k Change in top 100 predictive features when including cell subsets defined in Wang et al. l Change in multivariate model specific cell clusters that are predictive, as well as multivariate results Box plot: Lower bound is 1st quartile, center is median, upper bound is 3rd quartile, whiskers extend to 1.5*IQR beyond bound. N=number of patients.
