Extended Data Fig. 7: Subgroup analyses for ORR and DCR. | Nature Cancer

Extended Data Fig. 7: Subgroup analyses for ORR and DCR.

From: Hypoxia-responsive CEA-targeted CAR T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion: a phase 1 trial

Extended Data Fig. 7: Subgroup analyses for ORR and DCR.

ORR and DCR with 95% CIs in I.P. group (a-b) and I.V. group (c-d). In each plot, the point estimate (square) denotes the ORR or DCR for that subgroup, and the horizontal line represents the 95% CI, calculated using the Clopper-Pearson exact method. The vertical dashed line indicates the overall ORR or DCR for the entire I.P. or I.V. group. The selected subgroup in I.P. group was characterized by CEA IHC expression ≥90% and with peritoneal metastases. The selected subgroup in I.V. group was characterized by CEA IHC expression ≥90% and without liver metastases. Abbreviations: ORR, objective response rate; DCR, disease control rate; CI, confidence interval; CRC, colorectal cancer; I.P., intraperitoneal infusion; I.V., intravenous infusion; IHC, immunohistochemistry; FC, fludarabine and cyclophosphamide; DL1, dose level 1; DL2, dose level 2; DL3, dose level 3; DL4, dose level 4; G-CSF, granulocyte colony-stimulating factor.

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