Extended Data Fig. 9: Distribution of PC13 CAR T cells and cytokines in body fluids from representative patients. | Nature Cancer

Extended Data Fig. 9: Distribution of PC13 CAR T cells and cytokines in body fluids from representative patients.

From: Hypoxia-responsive CEA-targeted CAR T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion: a phase 1 trial

Extended Data Fig. 9: Distribution of PC13 CAR T cells and cytokines in body fluids from representative patients.

Tracking of CAR transgene copies and cytokines in peripheral blood and ascites from two representative patients, 003 (a-e) and 040 (f-j), in the I.P. group. Detection of CAR transgene copies in peripheral blood, ascites, and pleural effusion from three patients, 005 (k), 030 (l), and 045 (m) in the I.V. group. CAR transgene levels were quantified by qPCR. Abbreviations: I.P., intraperitoneal infusion; I.V., intravenous infusion; qPCR, quantitative real-time polymerase chain reaction.

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