Extended Data Fig. 3: Detection of PC13 CAR T cells in colonic biopsies of patients with immune-mediated colitis. | Nature Cancer

Extended Data Fig. 3: Detection of PC13 CAR T cells in colonic biopsies of patients with immune-mediated colitis.

From: Hypoxia-responsive CEA-targeted CAR T cells in CEA-positive solid tumors through intraperitoneal or intravenous infusion: a phase 1 trial

Extended Data Fig. 3: Detection of PC13 CAR T cells in colonic biopsies of patients with immune-mediated colitis.The alternative text for this image may have been generated using AI.

a, Representative IHC images of colonic biopsy tissues from the I.P. group, stained for CD3 and the PC13 CAR (40× magnification). qPCR analysis of CAR transgene copy numbers in colitis biopsy samples and paired peripheral blood from (b) Patient 028 and (c) Patient 029. Due to the limited size of each clinical biopsy, IHC was performed once per patient. Abbreviations: IHC, immunohistochemistry; I.P., intraperitoneal infusion; qPCR, quantitative real-time polymerase chain reaction.

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