Extended Data Fig. 4: Immune-mediated adverse events.

Nivolumab plus ipilimumab arm, n = 282; nivolumab arm, n = 318; durvalumab arm, n = 317. Immune-mediated AEs were AEs consistent with an immune-mediated mechanism or an immune-mediated component for which noninflammatory etiologies (eg, infection or tumor progression) were ruled out. aAll-cause pneumonitis included pneumonitis, immune-mediated lung diseases, and interstitial lung disease. One grade 5 pneumonitis event was reported in the nivolumab alone arm.