Fig. 2: Analysis of association of biological age acceleration with the risk of COVID-19.
From: Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
a Schematic representation of analysis of the biological age acceleration in the UKBB cohort. The box plots showing the distribution of biological age acceleration measured by phenotypic age (b), DOSI (c), and negative log physical activity (d) in UKBB subjects that were not tested, tested, or died with COVID-19 infection. Boxes indicate 25−75% interquartile ranges, and whiskers indicate minimum to maximum. The sample size (N) for each group is shown under the x-axis. e The forest plot is showing the predicted effect of biological age acceleration on the risk of COVID-19 in different categories. Error bars show the 95% confidential interval. Significant effects (P < 0.001) are in orange. Nominally significant effects (P < 0.05) are in black. The odds ratio for Phenotypic Age and Dynamic Organism State Index (DOSI) is given per 10-yr biological age acceleration. The odds ratio for physical activity is given per increase of 1000 steps/day. UKBB UK Biobank, DOSI Dynamic Organism State Indicator.
