Fig. 3: Bivariate genomic scan identified Notch signaling as an age-related COVID-19 risk.
From: Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
Gene set enrichment analysis of aging-related COVID-19. Top significantly enriched (Padjusted < 0.05) canonical pathways (a) and GO biological processes (b) are shown. c Forest plot showing Mendelian randomization estimates for the causal effect of blood NOTCH2 expression on the risk of COVID-19 infection. Error bars show the 95% confidential interval. Nominally significant effects (P < 0.05) are in black. Error bars show the 95% confidential interval. d, e Plots of effect size of all genetic instruments from blood eQTLs for NOTCH1 versus those for COVID-19 critical illness (d) and NOTCH2 versus UKBB COVID-19 infection (e). Error bars represent standard errors. f Bar plot showing the age-related differential expression of NOTCH1-4 in blood. The y-axis represents the −log10(P.adj) × sign of changing direction, i.e., the positive value represents an age-related increase. UKBB UK Biobank, HGI Host Genetics Initiative.
