Fig. 6: Expression of SARS-CoV-2 cell entry-related receptor and entry-associated proteases in different cell types of the mouse inner ear. | Communications Medicine

Fig. 6: Expression of SARS-CoV-2 cell entry-related receptor and entry-associated proteases in different cell types of the mouse inner ear.

From: Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction

Fig. 6

a, b The presence of ACE2, TMPRSS2, and FURIN in the mouse cochlea (a) and vestibule (b). In the cochlea, all 3 protein-positive cells are located in the OC, which contains sensory hair cells and supporting cells, the SGNs, which innervate hair cells, and the SV, which contains numerous blood vessels. In the vestibule, the cells co-expressing all 3 proteins are located in the saccule and utricle. Data are representative images from at least 3 independent experiments. Scale bars = 50 μm. c Small expression of ACE2 (indicated by yellow arrows) in MBP-expressing Schwann cells. Data are representative images from 3 independent experiments. Scale bars = 10 μm.

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