Fig. 1: The proteome and phosphoproteome are distinct between non-recurrent and recurrent HPV+ HNSCC.
From: Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma
a A schematic summary of quantitative mass spectrometry (MS) analysis of HPV+ HNSCC tumor and control tonsil samples. The number of proteins or phosphosites quantified in at least three samples in both the patient and control groups are shown. IMAC immobilized metal affinity chromatography, AP affinity purification, SH2S SH2 Superbinder. b The UMAP dimension reduction analysis of the proteome data to show segregation of recurrent (R) from the non-recurrent (NR) tumor proteome. c Volcano plot highlighting the significantly increased (red) or decreased (blue) proteins associated with recurrence. d Enriched biological processes in the recurrent compared to the non-recurrent tumors based on GO analysis of the corresponding proteome data. The circle size corresponds to the number of genes that belong to the GO term. e Significantly increased (red) or decreased (blue) phosphosites associated with recurrence. For panels c and e, n = 8 for the NR group, and n = 7 for the R group. f Enriched biological processes in the recurrent compared to the non-recurrent tumors based on the corresponding phosphoproteome data.
