Fig. 2: Remodeling of the tumor microenvironment (TME) underpins recurrence.
From: Proteome and phosphoproteome signatures of recurrence for HPV+ head and neck squamous cell carcinoma
a Heatmap of functional gene signatures (Fges) to show the significant changes in cellular or extracellular components (boxed) in the recurrent compared to the non-recurrent groups and tonsil controls. ECM extracellular matrix. b An increased EMT potential is associated with recurrence. The recurrent tumors were characterized with significantly increased expression of the markers for a partial EMT program (p < 0.1 between the NR and R groups). c Representative examples of pEMT markers with significant differences in expression between recurrent and non-recurrent samples. The box in a the box plot extends from the 25th to the 75th percentile. The whiskers go down to the smallest value and up to the largest. For the panels b and c, n = 8 for the NR group, and n = 7 for the R group.
