Fig. 7: Effect of 800CW-pRIS-DNV applied topically to mouse palatal tissue on tooth extraction wound healing of mice pretreated with ZOL. | Communications Medicine

Fig. 7: Effect of 800CW-pRIS-DNV applied topically to mouse palatal tissue on tooth extraction wound healing of mice pretreated with ZOL.

From: Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

Fig. 7

a Experimental protocol. b Intra-oral photographs depict gingival swelling (white dotted line) and the open tooth extraction wound (yellow arrows). c The gingival swelling area was dose dependently decreased by topical application of 800CW-pRIS-DNV (n = 8 per group). d Three-dimensional reconstruction of micro-CT images shows a region of osteoclastic resorption pits at the tooth extraction site (white arrow) after two applications of 800CW-pRIS-DNV. e The bone volume in the tooth extraction sockets dose-dependently increased with topical application of 800CW-pRIS-DNV. Graphs present mean and standard deviation (n = 5~7 per group). One-way analysis of variance (ANOVA) with Dunnett post hoc test was used. *p < 0.05; ***p < 0.001. Source data: Supplementary Data 1, Fig. 7c, e.

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