Fig. 4: Sequence alignment and structures of SARS-CoV-2 RBD variants.

a The sequence alignment chart of the RBD constructs used in this study, showing mutations noted in blue (Delta) and green (Omicron). b Structural surface and cartoon representation of WT SARS-CoV-2 RBD (grey, PDB: 6LZG), with color-coded surface mutations for Delta- (blue, PDB: 7WBQ) and Omicron-RBD (green, PDB: 7WBP)28,29. Note that most mutations cluster on the ACE2 binding interface.