Fig. 5: Schematic illustration of the main findings of the study. | Communications Medicine

Fig. 5: Schematic illustration of the main findings of the study.

From: Mendelian randomization prioritizes abdominal adiposity as an independent causal factor for liver fat accumulation and cardiometabolic diseases

Fig. 5

a Both genetically-predicted body mass index and abdominal adiposity are associated with non-alcoholic fatty liver disease (NAFLD) and liver fat accumulation. However, the relationship between genetically-predicted BMI and NAFLD/liver fat accumulation is entirely mediated by genetically-predicted abdominal adiposity. b Genetically-predicted abdominal adiposity and NAFLD/liver fat accumulation are both associated with type 2 diabetes (T2D) and their associations with T2D are largely independent from one another. Genetically-predicted T2D is also associated with NAFLD/liver fat accumulation. c Genetically-predicted abdominal adiposity, but not genetically-predicted NAFLD/liver fat accumulation is associated with coronary artery disease (CAD). The association between genetically-predicted abdominal adiposity and CAD is not mediated by NAFLD/liver fat accumulation.

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